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The orally-disintegrating tablets have been designed to rapidly dissolve on the tongue and can be swallowed with salivaEnsure that your hands are dry when you remove the tablet from its blister packagingand then immediately place the tablet on your tongueNote that tablets must be used immediately after removal from packagingThe tablets cannot be stored once they are removed from their packaging.

Safety and effectiveness of mirtazapine in the pediatric population have not been establishedsee PRECAUTIONS

Concomitant administration of diazepam15 mghad a minimal effect on plasma levels of mirtazapine15 mgin 12 healthy subjectsHoweverthe impairment of motor skills produced by REMERON has been shown to be additive with those caused by diazepamAccordinglypatients should be advised to avoid diazepam and other similar drugs while taking REMERON.

Antidepressant medications are used to treat a variety of conditionsincluding depression and other mental/mood disordersThese medications can help prevent suicidal thoughts/attempts and provide other important benefitsHoweverstudies have shown that a small number of peopleespecially people younger than 25who take antidepressants for any condition may experience worsening depressionother mental/mood symptomsor suicidal thoughts/attemptsThereforeit is very important to talk with the doctor about the risks and benefits of antidepressant medicationespecially for people younger than 25even if treatment is not for a mental/mood condition.

Adverse events reported since market introductionwhich were temporallybut not necessarily causallyrelated to mirtazapine therapyinclude cases of the ventricular arrhythmia Torsades de PointesIn the majority of these caseshoweverconcomitant drugs were implicatedCases of severe skin reactionsincluding Stevens-Johnson syndromebullous dermatitiserythema multiforme and toxic epidermal necrolysis have also been reportedIncreased creatine kinase blood levels and rhabdomyolysis have also been reported.

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